- Über NIFE
Director of Clinic/Institute: Prof. Dr. Axel Haverich
Representative at the NIFE: Dr. Sotirios Korossis
Keywords: Biohybrid lung, biohybrid VAD, bioactive coatings, endothelialisation, heart valve implants, mitral valve vascular stents, 3D bioprinting, computational modelling, computational fluid dynamics (CFD), finite element (FE) analysis, pattern recognition, tissue engineering heart valves, decellularised scaffolds, cardiovascular bioreactors, biomechanics, haemodynamics, biocompatibility, disease modelling, implant infection.
The CARE group is currently focused on the following five major projects:
Tissue engineering: This work focuses on the development of decellularised valvular scaffolds, which can either implanted without cells, or can be seeded with autologous cells and conditioned in a bioreactor, in order to develop valve-equivalent functionality prior to implantation. The work is also focused on developing methodologies for the 3D printing of scaffolds for tissue engineering.
Biohybrid devices: This project focuses in the development of bioactive coatings and methods for tethering endothelial cell attachment on the artificial blood-contacting surfaces of extracorporeal membrane oxygenators and ventricular assist devices (VADs). Consolidating these technologies, the work also focuses on the development of a fully implantable biohybrid intracorporeal membrane oxygenator (iCMO).
Implant infection: The work in this project is focused on developing solutions for inducing antimicrobial resistance to cardiovascular implants.
Patient-specific computational modelling: This project is focused on fluid-solid-interaction (FSI) computational models of the heart using patient-specific anatomies, with a view to developing a prognostic virtual platform that will enable cardiac surgeons to make patient-specific pre-operative decisions by optimising valve replacement and repair, and VAD implantation. This work also focuses in developing disease-specific models for assessing oxygenator function and operation.
Near-physiological in vitro testing: This work is focused on developing in vitro near-physiological methodologies for assessing the biomechanical and haemodynamic function of cardiovascular and pulmonary implants, aiming to reduce, refine and replace (3Rs) animal testing.