Bacteriophages (or phages) are viruses that can only infect bacterial cells. They are divided into two main types, lytic phages and temperate phages. Lytic bacteriophages can be used as antibacterial agents because they do not integrate into the host bacterial genome and active infection results in bacterial dissolution (cell lysis).


Prof. Dr.
Christian Kühn
Clinic for Heart, Thorax, Transplant and Vascular Surgery

Selected publications

Rubalskii E, Ruemke S, Salmoukas C, Boyle EC, Warnecke G, Tudorache I, Shrestha M, Schmitto.
JD, Martens A, Rojas SV, Ziesing S, Bochkareva S, Kuehn C, Haverich A. Bacteriophage Therapy for.
Critical Infections Related to Cardiothoracic Surgery. Antibiotics (Basel). 2020 May 5;9(5):232. doi:
10.3390/antibiotics9050232. PMID: 32380707; PMCID: PMC7277081.

Rubalskii E, Ruemke S, Salmoukas C, Aleshkin A, Bochkareva S, Modin E, Mashaqi B, Boyle EC,
Boethig D, Rubalsky M, Zulkarneev E, Kuehn C, Haverich A. Fibrin glue as a local drug-delivery.
system for bacteriophage PA5. Sci Rep. 2019 Feb 14;9(1):2091. doi: 10.1038/s41598-018-38318-4. PMID:
30765740; PMCID: PMC6376040.

Fursov MV, Abdrakhmanova RO, Antonova NP, Vasina DV, Kolchanova AD, Bashkina OA, Rubalsky.
OV, Samotrueva MA, Potapov VD, Makarov VV, Yudin SM, Gintsburg AL, Tkachuk AP, Gushchin.
VA, Rubalskii EO. Antibiofilm Activity of a Broad-Range Recombinant Endolysin LysECD7: In Vitro
and In Vivo Study. Viruses. 2020 May 15;12(5):545. doi: 10.3390/v12050545. PMID: 32429199; PMCID:

Salmoukas C, Ruemke S, Rubalskii E, Burgwitz K, Haverich A, Kuehn C. Vascular Graft Pre-.
Treatment with Daptomycin Prior to Implantation Prevents Graft Infection with Staphylococcus
aureus in an In Vivo Model. Surg Infect (Larchmt). 2020 Mar;21(2):161-168. doi: 10.1089/sur.2019.124.
Epub 2019 Oct 1. PMID: 31573423.

Ruemke S, Rubalskii E, Mashaqi B, Burgwitz K, Haverich A, Salmoukas C, et al. Evaluation of Gram-.
Positive and Gram-Negative Bacterial Adherence on Four Different Vascular Prosthetic Grafts In
Vitro. Austin J Surg. 2019; 6(15): 1200.


Prof. Dr. Christian Kühn


Hanover Medical School
Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery
Carl-Neuberg-Str. 1
30625 Hanover