Drug Delivery System and Target-Associated Cytostatic Drug Formulation

The WG is working on the development of an innovative drug delivery system and target-associated cytostatic drug formulation for the clinical establishment of intrathoracic chemoaerosol therapy as a new treatment modality for thoracic-associated malignancies.


Norman Zinne
Clinic for Heart, Thorax, Transplant and Vascular Surgery
Patrick Zardo
Clinic for Heart, Thorax, Transplantation and Vascular Surgery

Selected publications

Wronski S, Beinke S, Obernolte H, Belyaev NN, Saunders KA, Lennon MG, Schaudien D, Braubach P, Jonigk D, Warnecke G, Zardo P, Fieguth HG, Wilkens L, Braun A, Hessel EM, Sewald K; U-BIOPRED Study Group. Rhinovirus-induced human lung tissue responses mimic COPD and asthma gene signatures. Am J Respir Cell Mol Biol. 2021 Jun 28. doi: 10.1165/rcmb.2020-0337OC. Epub ahead of print. PMID: 34181859.

Zhong S, Golpon H, Zardo P, Borlak J. miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer. Transl Res. 2021 Apr;230:164-196. doi: 10.1016/j.trsl.2020.11.012. epub 2020 Nov 28. PMID: 33253979.

Renne J, Gutberlet M, Voskrebenzev A, Kern A, Kaireit T, Hinrichs J, Zardo P, Warnecke G, Krüger M, Braubach P, Jonigk D, Haverich A, Wacker F, Vogel-Claussen J, Zinne N. Multiparametric MRI for organ quality assessment in a porcine ex vivo lung perfusion system. PLoS One. 2018 Dec 27;13(12):e0209103. doi: 10.1371/journal.pone.0209103. PMID: 30589907; PMCID: PMC6307703.

Renne J, Gutberlet M, Voskrebenzev A, Kern A, Kaireit T, Hinrichs JB, Braubach P, Falk CS, Höffler K, Warnecke G, Zardo P, Haverich A, Wacker F, Vogel-Claussen J, Zinne N. Functional Pulmonary Magnetic Resonance Imaging for Detection of Ischemic Injury in a Porcine Ex-Vivo Lung Perfusion System Prior to Transplantation. Acad Radiol. 2019 Feb;26(2):170-178. doi: 10.1016/j.acra.2018.05.006. epub 2018 Jun 19. PMID: 29929935.

Neuhaus V, Danov O, Konzok S, Obernolte H, Dehmel S, Braubach P, Jonigk D, Fieguth HG, Zardo P, Warnecke G, Martin C, Braun A, Sewald K. Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices. J Vis Exp. 2018 May 9;(135):57042. doi: 10.3791/57042. PMID: 29806827; PMCID: PMC6101160.

Starke H, Zinne N, Leffler A, Zardo P, Karsten J. Developing a minimally invasive anaesthesiological approach to non-intubated uniportal video-assisted thoracoscopic surgery in minor and major thoracic surgery. J Thorac Dis. 2020;12: 7202-7217. doi:10.21037/jtd-20-2122.

PITAC, HITOC, chemotherapy, cisplatin, aerosol, pleural mesothelioma, thoracic

Dr. Norman Zinne

+49 511 532 6591


Dr. Patrick Zardo

+49 511 532 3455


Clinic for Heart, Thorax, Transplant and Vascular Surgery
Hanover Medical School