Graded implants and regenerative strategies in the skeletal system

The high prevalence of musculoskeletal diseases makes innovative treatment approaches necessary. This can be made possible by optimized biomedical implants and stem cells as partial aspects of regenerative medicine, and this is also the focus of the group´s work. We bring basic scientific results, e.g. from signal pathways, into biomedical applications.


Univ.-Prof. Dr. rer. nat.
Andrea Hoffmann
Kirsten Elger
M. Sc.
Nina Friese
PhD student
M. Sc., PhD student
Mattis Gierschner
Anika Hamm
Yvonne Roger
Dr. rer. nat.
Patrik Schadzek

Selected publications of the last 5 years 
*: equivalent contributions, #: correspondence.

Friese, N., Gierschner, M.B., Schadzek, P., Roger, Y., Hoffmann, A. (2020).:
Regeneration of Damaged Tendon-Bone Junctions (Entheses): TAK1 as a Potential Node Factor.
Int J Mol Sci;21:E5177.
Lavrentieva, A.*, Hoffmann, A.*, Lee-Thedieck, C.* (2020):
Limited Potential or Unfavorable Manipulations? Strategies Toward Efficient Mesenchymal Stem/Stromal Cell Applications.
Front Cell Dev Biol;8:316

Roger, Y., Sydow, S., Burmeister, L., Menzel, H., Hoffmann, A.# (2020):
Sustained release of TGF-β3 from polysaccharide nanoparticles induces chondrogenic differentiation of human mesenchymal stromal cells.
Colloids Surf B Biointerfaces;189:110843

Roger, Y., Burmeister, L., Hamm, A., Elger, K.., Dittrich-Breiholz, O., Flörkemeier, T.*, Hoffmann, A.* # (2020):
Heparin Anticoagulant for Human Bone Marrow Does Not Influence In Vitro Performance of Human Mesenchymal Stromal Cells.

Winkel, A., Jaimes, Y., Melzer, C., Dillschneider, P., Hartwig, H., Stiesch, M., von der Ohe, J., Strauss, S., Vogt, P.M., Hamm, A., Burmeister, L., Roger, Y., Elger, K.., Flörkemeier, T., Weissinger, E.M., Pogozhykh, O., Müller, T., Selich, A., Rothe, M., Petri, S., Köhl, U., Hass, R., Hoffmann, A.# (2020):
Cell culture media notably influence properties of human mesenchymal stroma/stem-like cells from different tissues.

Gniesmer, S., Brehm, R., Hoffmann, A., de Cassan, D., Menzel, H., Hoheisel, A.-L., Glasmacher, B., Willbold, E., Reifenrath, J., Ludwig, N., Zimmerer, R., Tavassol, F., Gellrich, N.-C., Kampmann, A. (2020):
Vascularization and biocompatibility of poly(ε-caprolactone) fiber mats for rotator cuff tear repair.
PLoS One;15(1):e0227563.

Schwieger, J., Hamm, A., Gepp, M.M., Schulz, A., Hoffmann, A., Lenarz, T., Scheper, V. (2020):
Alginate-encapsulated Brain Derived Neurotrophic Factor-overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons.
J Tissue Eng.;11:1-15

De Cassan, D., Becker, A., Glasmacher, B., Roger, Y., Hoffmann, A., Gengenbach, T. R., Easton, C. D., Hänsch, R., Menzel, H.. (2020):
Blending chitosan-g-poly(caprolactone) with poly(caprolactone) by electrospinning to produce functional fiber mats for tissue engineering applications.
J Appl Polym Sci; DOI: 10.1002/APP.48650.

Willbold, E.; Wellmann, M. Welke, B., Angrisani, N., Gniesmer, S., Kampmann, A., Hoffmann, A., De Cassan, D., Menzel, H., Hoheisel, A.-L., Glasmacher, B., Reifenrath, J. (2020):
Possibilities and limitations of electrospun chitosan-coated polycaprolactone grafts for rotator cuff tear repair
J Tissue Eng Regen Med;14(1):186-197

Scheper, V., Schwieger, J., Hamm, A., Lenarz, T., Hoffmann, A. (2019):
BDNF-overexpressing human mesen¬chymal stem cells mediate increased neuronal protection in vitro.
J Neurosci Res;97(11):1414-1429

Weist, R., Flörkemeier, T., Roger, Y., Noack, S., Franke, A., Schwanke, K., Zweigerdt, R., Mar¬tin, U., Willbold E.*, Hoffmann, A.* # (2018):
Differential expression of cholinergic system components in human induced pluripo¬tent stem cells, bone marrow-derived multipotent stromal cells, and induced pluripotent stem cell-derived multipotent stromal cells.
Stem Cells Dev;27;166-183

Hoffmann, A., Floerkemeier, T., Melzer, C., Hass, R.. (2017):
Comparison of in vitro-cultivation of human mesenchymal stroma/stem cells derived from bone marrow and umbilical cord.
J Tissue Eng Regen Med; 11(9):2565-2581.

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Musculoskeletal implants, tendons, fibrosis, immune responses, mesen¬chymal stem cells, signaling pathways regeneration, signaling pathways inflammation, bone sarcomas, lentiviral expression systems.

Prof. Dr. Andrea Hoffmann

+49 (0)511 532 1442


Stadtfelddamm 34
30625 Hanover

  • Prof. Dr. Andrea Hoffmann: Spokesperson of the DFG-FOR 2180, member of the wiss. Advisory Board of the "Rostock Centre for Interdisciplinary Implant Research
    ROCINI, Member of AcademiaNet
  • Adult stem cells in regenerative medicine (lecture)
  • Development of cell therapeutics: Experimental Applications and Clinical Use of Adult Stem Cells (Lecture Series).
  • Introduction to animal cell culture technology (practical course in NIFE).
More additional info
  • Teaching Award 2021
  • best elective module 2022