Organ synthesis/3D histology

We microtome embedded organs into large-scale, dimensionally stable section stacks, scan them after histological staining and reconstruct an in silico 3D histological image with a resolution of 0.9µ. After segmentation, a proprietary 3D printing process is used to generate stromal structures that can be subsequently colonized parenchymal.

Research

In this case, the boundary conditions can be made somewhat more flexible:
  • The biological materials do not have to be printable
  • The printing process does not have to be biocompatible in every respect

This technique is based on:

  • The expression of parenchyma-separating segment structures obtained from the digitized 3D organ data
  • Subsequent replacement of the pressure material with stromal support material suitable for parenchymal functionalization
GROUP LEADER
Prof. Dr.
Axel Haverich
Cardiac, Thoracic, Transplantation and Vascular Surgery
Keywords
Organ synthesis, large area histology, 3D histology
Contact

Dr. Roland Rohde

+49 (0)511 532 8847

Rohde.Roland(at)mh-hannover.de

NIFE
Stadtfelddamm 34
30625 Hanover

Specials

Patents

More additional info

Somogyi J, 3D vascular tree segmentation using neural networks, Master's thesis M-01/20-919.

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