Three projects each from the MHH, the University Medical Center Göttingen (UMG) and the Helmholtz Centre for Infection Research (HZI) took part in the second round of the Institute for Biomedical Translation (IBT) Lower Saxony competition. In addition to the Bacta Implants project, the HZI project PROTON convinced the jury. It is developing a technology to prevent dangerous bacterial infections and will receive funding of around 890,000 euros. Service: The press release of the IBT you will find here. More information can be obtained from PD Dr. Verena Scheper, scheper.verena@mh-hannover.de. Text: Kirsten Pötzke
Lower Saxony research incubator Institute for Biomedical Translation (IBT) supports MHH project Bacta Implants with 770,000 euros
The Institute for Biomedical Translation (IBT) aims to translate cutting-edge biomedical research into clinical practice. To this end, the IBT has awarded start-up funding of more than 1.6 million euros in the second funding round. Nine research projects took part in the final round of the competition for the funding, and the jury has now selected two winners. One of them is the Bacta Implants project led by Dr. Verena Scheper, a scientist at the Department of Otorhinolaryngology (ENT) at Hannover Medical School (MHH). Together with her team, she is developing implants for the treatment of hearing disorders. The project is now being supported by the IBT with around 770,000 euros over two years. "This funding enables us to conduct a clinical study to prove that our idea works," says PD Dr. Scheper. MHH President Professor Dr. Michael Manns is also delighted with the success: "The translation of cutting-edge clinical research into application is the driving force for better patient care. The IBT accelerates this transfer as an incubator through start-up funding."
Implant releases active substances locally
Bacta Implants enables the targeted delivery of active substances to areas of the body that are difficult to access. The first goal of the platform technology is to combat hearing loss. Using 3D printing with a bio-plotter, an elastic implant is created from silicone that contains an active ingredient to combat hearing loss and is precisely adapted to the individual patient's anatomy. The implant can be inserted directly into the so-called round window niche, which connects the middle ear with the inner ear, via a small incision in the eardrum under local anesthetic. Until now, sudden hearing loss has been treated with tablets or injections. The problem with this is that only a small proportion of the active ingredients used reach the inner ear. Therefore, either the healing effect is too low or the dose must be so high that undesirable side effects occur. "Both can be avoided with our implant because the active ingredient does not have to take a detour and can be targeted to the right place," emphasizes PD Dr. Scheper.Individual healing trials already successful
The round window implant (RNI) has already been effectively tested on patients with sudden hearing loss in individual treatment trials. However, before PD Dr. Scheper and her two colleagues from the ENT clinic can set up their own company and put their innovative development into practice, the team must prove in a clinical trial that the RNI actually delivers the drug to the inner ear. "This first study is a prerequisite for us to be able to conduct a registration study," says the scientist. Now she and her colleagues are delighted that the prize money from the IBT start-up competition will provide them with the financial means to prove this.