Group leader: Prof. Dr. Meike Stiesch (firstname.lastname@example.org)
Clinic for Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625 Hannover
Biofilms; implant-associated infections; oral microbiome; surface development; antibacterial characterization of surfaces; cytocompatibility; 3D models; multispecies biofilm models; co-culture models; in vivo experiments; phage research; stem cell research; tissue engineering
NGS sequencing (PacBio Sequel); atomic force microscopy (Nanosurf Flex-FPM); CLSM (Leica SP8); qPCR (Roche Lightcycler & BioRad iQ5); Agilent 2100 Bioanalyzer; luminescence/fluorescence plate reader (Tecan Infinite M200 PRO); anaerobic, microaerophilic and aerobic cultivation of microorganisms under static and dynamic conditions; laboratory facilities up to safety level S2
The research group of Prof. Stiesch has many years of expertise in the characterization of biofilm associated-infections as well as the development of innovative strategies for biofilm diagnostic, prevention and therapy. Although the field of biomedical engineering is under rapid improvement, implant-associated infections still remain one of the major challenges in modern medicine. These infections can not only lead to implant loss, but may also be associated with life-threatening conditions. New standards are set in the prevention and therapy through development of innovative implant materials or surface functionalization with long-lasting anti-biofilm effects and good biointegration. These implants are developed for specific clinical situations in regard to drug release, stability as well as patient variations. Physically and chemically modified surfaces are tested in static and dynamic biofilm models, 3D-tissue models and implemented in vivo models. For early diagnosis and personalized therapy of implant-associated infections biomarkers are characterized with state of the art molecular biology techniques. The Biobank BIT (Biofilms, Implants, Tissues) serves as the backbone for the analysis of complex relationships between implants, biofilms, local and systemic inflammation processes with its collection of implant-associated material from various medical disciplines.